Hot off the Press
A Synthetic Superoxide Dismutase/Catalase Mimetic EUK-207 Mitigates Radiation Dermatitis and Promotes Wound Healing in Irradiated Rat Skin. Doctrow SR, Lopez A, Schock AM, Duncan NE, Jourdan MM, Olasz EB, Moulder JE, Fish BL, Mäder M, Lazar J, Lazarova Z. J Invest Dermatol. 2012 Nov 29. doi: 10.1038/jid.2012.410. [Epub ahead of print]
A focus in my research over the past couple of years has been the effects of ionizing radiation on the skin. A potential contributor to the progression of delayed radiation-induced injury to the skin and other organs is thought to be chronic oxidative stress. EUK-207 is a synthetic superoxide dismutase catalase mimetic that scavenges reactive oxygen and nitrogen species. We used EUK-207 to examine the causative role oxidative stress plays in delayed radiation-induced injury in a rat model of combined irradiation and wound injury. Our results showed that EUK-207 mitigated radiation dermatitis, suppressed indicators of tissue oxidative stress, and enhanced wound healing. These results demonstrate that oxidative stress plays a critical role in the progression of radiation-induced skin injury, and that this injury can be mitigated with the appropriate antioxidant compounds. This work was recently published in the Journal of Investigative Dermatology: A Synthetic Superoxide Dismutase/Catalase Mimetic EUK-207 Mitigates Radiation Dermatitis and Promotes Wound Healing in Irradiated Rat Skin.
Our work could not have been completed without the fruitful collaboration with members of the Radiation Oncology department at MCW and the Department of Medicine from Boston University.
In addition, Argelia Lopez Luna, my graduate student from the University of Autonoma de Zacatecas in Mexico, worked on this project for 3 years; culmination of her hard work lead to a successful defense of her doctoral thesis for which she earned high honors. The University Autonoma de Zacatecas has praised our department for our nurturing scientific environment and is looking forward to future scientific collaboration.