Active Pediatric Research Studies

Active Pediatric Research Studies

Principal InvestigatorTitleDescription
Influence of Demographic Factors in Those Affected by BirthmarksThe purpose of this study is to determine if there are specific demographic/environmental factors that are common in people with birthmarks or congenital anomalies of the skin. This information will allow physicians to examine possible causes and improve care for patients diagnosed with these conditions. Enroll all of those patients diagnosed with a birthmark seen in Pediatric Dermatology Group and/or Vascular Anomalies Center at Children’s Hospital of Wisconsin/Medical College of Wisconsin. We anticipate approximately 3000 patients over 10 years will enroll in the study, collecting pertinent demographic factors and monitoring clinical outcomes.
Genetic Basis of HemangiomasThe purpose of this study is to enroll a cohort of 440 children into the study to monitor clinical outcomes and collect DNA samples from all subjects and biological parents; enroll a cohort of 440 healthy children (and biological parents) and collect DNA samples. The goal is to identify novel genes that contribute to the risk of infantile hemangiomas using family-based genomewide association analysis approach as well as a case control approach. Correlating the data derived from the genetic analysis to clinical outcomes and associated anomalies in order identify genetic biomarkers that will guide diagnosis and therapeutic interventions.
Genetic Analysis of PHACEThe purpose of this study is to determine if there are genes that are common in the cause of PHACE syndrome. Identification of causal gene(s) in PHACE syndrome would contribute to a better understanding of the molecular pathways involved in hemangiomas.
Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes in PHACE SyndromeThe purpose of this study is to establish a cohort of 30 subjects from ages 4 to 18 years of age; define the functional and neurodevelopmental outcome of PHACE syndrome and identify potential biomarkers that predict progressive vasculopathy, ischemic stroke, and neurodevelopmental impairment.
The Atopic Dermatitis Clinic as an Entry Point for Community Outreach in Asthma, Missed Immunization and Vitamin D DeficiencyThe purpose of this study is to evaluate the prevalence of common health issues in our community in our atopic dermatitis patient population. We aim to show that children with atopic dermatitis in Milwaukee have an increased prevalence of undiagnosed asthma, missed immunizations and vitamin D deficiency.
Treatment of Vitamin D Deficiency and Effect on Atopic DermatitisThe purpose of this randomized trial is to examine the effects of vitamin D treatment on atopic dermatitis severity in patients with diagnosed vitamin D deficiency. Additionally, the goal is the demonstrate that high dose vitamin D is more effective than standard dose vitamin D in correcting serum 25-hydroxyvitamin D deficiency and improving atopic dermatitis.
Longitudinal Characterization of Pediatric-Onset MorpheaThis study aims to better understand the natural history and clinical features of morphea. A retrospective review of our institutional experience with this disease is combined with a prospective registry. Standardized assessments will be completed at each visit. A tissue bank consisting of blood and skin samples will be accumulated over time to allow for translational research projects in the future.
Evaluation of Endothelial Progenitor Cells and Hypoxia-Induced Mediators of EPC Trafficking in Patients with Infantile HemangiomasThe purpose of this pilot study is to investigate the relationship between the presence of infantile hemangiomas and levels of circulating endothelial progenitor cells (EPCs) and the mediators of EPC trafficking in a group of patients with infantile hemangiomas and age-matched healthy controls.
International Registry for Vascular Anomalies Associated with CoagulopathyA longitudinal cohort study of vascular anomalies associated with coagulopathy to describe clinical features, histopathological features, prognosis and therapeutic options. The goal is to provide an international resource for physicians and families by establishing diagnostic guidelines and developing standards of care for evaluation and treatment of kids with vascular anomalies associated with coagulopathy.
Vascular Malformations and Abnormalities of GrowthThe primary goal of this pilot study is to identify potential biomarkers for patients with vascular malformations and variable clinical phenotypes that are potentially be tested in larger clinical trials. Patients with vascular malformations will be evaluated for global or mosaic growth abnormalities in an effort to assess the extent of these associations. Patients will be clinically evaluated for growth abnormalities and will have systematic molecular studies performed to detect abnormalities in the P13 kinase/AKT signaling pathway.
Natural History of Urticaria Pigmentosa in ChildrenThe purpose of this study is to assess duration of disease as well as associated symptoms and complications in children with urticaria pigmentosa. Patients will be followed prospectively over time until resolution of their disease.
The Spectrum of Congenital Melanocytic Nevi
Clinical and Genetic Analysis of Genetic Skin Diseases
A Phase II, Randomized Clinical Trial Assessing Efficacy and Safety of Oral Prednisolone vs. Intravenous Vincristine in the Treatment of Infantile Hemangiomas
Congenital Hemangiomas of Infancy, Clinical Characteristics and Relationship to Race, Sex, Gestation, and Treatment Outcomes
Hemangioma Associated with High Rates of Morbidity: Prospective Evaluation and Long-term Outcome of Large Facial, Lumbosacral and Multiple Hemangiomas
Retrospective Review of Risk Factors for Stroke Among Patients with PHACE Syndrome